Check out the NFL pick for Monday, December 22, 2025 along with other information listed below.

NFL Pick for Monday, December 22, 2025

• SFO -5.5 (-110)

Unit Play: $4.40 to win $4

We only have one game tonight, so we’ll try the 49ers spread as they have covered five straight road games as a favorite.

NFL Pick Tracker

• Last Pick: NYJ/NOR U41 (-110)
• Record: 21-23-4
• Bank Count: +111.70

2024: 29-34-2, +0.45