Check out the NFL betting trends for Week 16 games on Monday, December 22, 2025 listed below.

49ers at Colts Game Trends

Venue Stats: Lucas Oil Stadium – 48.3 ppg; 3-3 O/U

• Indianapolis has lost 11 straight games when facing the NFC as the underdog. Indianapolis faces San Francisco as the underdog with a 29.9% chance to win.

• San Francisco has covered the spread in 5 straight road games when playing as a favorite. San Francisco faces Indianapolis as the favorite given a 51.9% chance to cover -6.5-points.

• Indianapolis Over 4 of 5 home games as an underdog.

NFL TD Trends

• Philip Rivers 10 straight games
• Brock Purdy 2+ 5 straight games as favorite in December
• Christian McCaffrey 6 straight games as favorite
• Jonathan Taylor 4 straight home games in December
• Jauan Jennings 4 straight games vs team on losing streak as favorite
• Tyler Warren 3 of 4 home games
• George Kittle 3 of 4 road games vs team over .500

NFL Yards Trends

• Brock Purdy 255+ 3 straight games vs AFC as favorite in December
• Philip Rivers 164+ 10 straight home games
• Jonathan Taylor 96+ 3 straight home games in December
• George Kittle 67+ 5 straight games
• Christian McCaffrey 64+ 6 straight games as favorite in December